华人医生数据库 Chinese Speaking Doctors in US and Canada

Xianfeng Frank, Zhao  MD, Ph.D.
Attending, Clinical Professor and Department Chair
Pathology Hematopathology Molecular Genetic Pathology

Education:
Shandong, Shandong Medical University

Main Office:
410-328-5555   University of Arizona College of Medicine Phoenix
550 E. Van Buren St  
Phoenix, AZ 85004

Clinic Intersts:
hematopathology.

Ph.D.:  University of Western Ontario

Research Interests:
Dr. Zhao has been interested in the discovery of biomarkers for the diagnosis
and molecular targets for the treatment of diffuse large B-cell lymphoma (DLBCL). Based on his
observation that RPS6KB1 and CDC2 genes were amplified in a subset of DLBCL, he and his coworkers
evaluated the activity of RPS6KB1 and CDC2 gene products in DLBCL and found that their activities
were responsible for the proliferation of lymphoma cells. Targeting their products inhibited the
proliferation and led to apoptosis of the lymphoma cells. In collaboration with numerous
physicians/scientists nationwide, he also investigated the molecular mechanism of lymphoma
development, particularly the crosstalk between the different signal transduction pathways of DLBCL.
Dr. Zhao recently became interested in HIV-related malignant lymphomas. He will continue to pursue
both independent and collaborative endeavors in discovering novel biomarkers and understanding the
molecular biology of hematologic malignancies.